The Hedgehog (Hh) pathway plays central roles in animal development and stem-cell function. Defects in Hh signalling lead to birth defects and cancer in humans. The first and often genetically ...

The hedgehog (Hh) signaling pathway regulates the differentiation and growth of numerous cell types, including chondrocytes, and thus is essential for normal skeletal development. Pharmacological ...

Chickens treated to inhibit the sonic hedgehog (Shh) pathway during development grow feathers that resemble ancient ...

本研究针对多发性骨髓瘤(MM)患者对一线药物来那度胺(LEN)的获得性耐药机制展开探索。南京第二医院团队发现转录因子YY1通过结合AKR1C3启动子区激活其表达，进而激活Hedgehog信号通路，促进糖酵解代谢重编程，最终导致LEN耐药。该研究揭示了YY1-AKR1C3-Hedgehog轴在MM ...

Feathers may have started as simple filaments in ancient dinosaurs, but a team of Swiss researchers is digging deep into the ...

Several components of the hedgehog (Hh) pathway are crucial to basal cell ... The requirement for canonical Wnt/β-catenin signaling in Hh-driven BCC development is increasingly recognized.

Feathers are complex skin structures, and their evolutionary beginnings are still a subject of scientific debate. Scientific evidence points to feathers evolv ...

studies the role of molecular signaling pathways (communication systems that transmit messages within and between cells), such as the Sonic Hedgehog (Shh) pathway, in the embryonic development of ...

Endeavor BioMedicines, a clinical-stage biotechnology company developing medicines with the potential to deliver transformational clinical benefits to patients with life-threatening diseases, today ...