总而言之，本研究首次在秀丽隐杆线虫模型系统中揭示了harmine的抗Ras活性。 本研究结果揭示了有害物质的潜在抗癌机制，它可能有助于治疗与致癌 ...

Harmine 减轻 LPS 诱导的 ALI：Harmine 预处理或治疗均可降低 LPS 诱导的 BALF 中蛋白质浓度和细胞数量、肺干湿重比及肺损伤评分，改善肺组织的病理变化，减少中性粒细胞和巨噬细胞的浸润，降低 ICAM-1 和 VCAM-1 的转录水平，有效减轻 LPS 诱导的 ALI。

特别值得注意的是，Harmine在抑制转移的同时保持良好安全性，这对改善青少年患者长期生存质量具有重要临床意义。未来研究可进一步优化Harmine衍生物结构，探索其与现有化疗药物的协同效应。

Harmine则能够通过抑制DYRK1A解除这些限制，促进β细胞的增殖。 GLP-1RA： 即胰高糖素样肽-1受体激动剂，是近年来新型的2型糖尿病治疗药物。

糖尿病治疗新突破！Sci Transl Med：Harmine和Exendin-4的联合使用能够安全地增加糖尿病患者体内β细胞的数量. 来源：生物谷原创 2024-08-19 12:00 ...

Human neural progenitors exposed to harmine, an alkaloid presented at the psychotropic plant decoction ayahuasca, led to a 70 percent increase in proliferation of these cells. The effect of ...

A recent study published in the Journal of Psychopharmacology highlights the potential synergy between meditation and psychedelics. Meditators who received a combination of DMT and harmine ...

A drug derived from a flowering plant found in the Middle East and in some South American vines appears to drive human insulin-producing beta cells to multiply, according to research published in ...

Harmine: Future Diabetes Drug Class? A novel drug candidate, harmine, can trigger human insulin-producing beta cells to multiply, new research has shown. A novel drug candidate, harmine, can ...

The new study, titled, “Harmine and exendin-4 combination therapy safely expands human b cell mass in vivo in a mouse xenograft system,” was published in Science Translational Medicine ...