值得注意的是，CRISPR-nuPin策略可能适用于许多其他DNA病毒。 图3 HSV-1早期核内生命阶段科学假说示意图 中山大学医学院研究生向娟、范朝阳为该论文 ...

基于mRNA递送的CRISPR治疗病毒性角膜炎的研究。该疗法利用的是慢病毒载体mRNA递送平台，命名为HELP（HSV-1-erasing lentiviral particles）。利用HELP技术 ...

Similarly, in another study, a single HSV-1-targeting CRISPR was injected ... The studies suggest that topical application of AAV-expressing CRISPR/Cas9 editing machinery can effectively prevent ...

(“Excision”, the “Company”), a clinical-stage biotechnology company developing CRISPR ... herpes simplex virus-1 keratitis program, EBT-104, as well as an overview of a next-generation AAV ...

(“Excision”, the “Company”), a clinical-stage biotechnology company developing CRISPR ... levels of AAV vector genomes in the trigeminal ganglia (TG) where the latent HSV-1 resides.

EBT-104 is a CRISPR-based gene therapy designed to potentially eliminate HSV-1 keratitis by inactivating latent HSV-1 in the latent HSV-1 reservoirs. The candidate utilizes a multiplexed CRISPR ...

Conventional CRISPR nucleases, including Cas9 and Cas12a, exceed the packaging limits of a single AAV vector, necessitating dual-AAV strategies that reduce efficiency. Smaller CRISPR systems such ...