CD24是HMGB1，HSP70，HSP90蛋白的负调控因子，它能降低这些蛋白的活性，还能抑制核因子κB（nuclear factor-kappa B，NF-κB）的活性。在生物模型小鼠的研究中发现这一负调控功能的实现很大程度上依赖Siglec-10或Siglec-G。 这些研究结果显示CD24-Siglec-G通路具有保护宿主的 ...

Here we use an intestinal perforation model of sepsis to show that microbial sialidases target the sialic acid–based recognition of CD24 by SiglecG ... stimulated with HMGB1 or HSP70 for 6 ...

HMGB1 is a non-histone nuclear protein that can serve as an alarmin to drive the pathogenesis of inflammatory and autoimmune disease. Although primarily located in the cell nucleus, HMGB1 can ...

As a novel innate immune checkpoint, CD24 orchestrates immune evasion through its interaction with the inhibitory receptor Siglec-10 (sialic-acid-binding Ig-like lectin 10) expresses on tumor ...

CD24 interacts with the macrophage receptor Siglec-10, and shields cancer cells from attack by macrophages. Pheast has engineered PHST001 to bind CD24 on the surface of cancer cells with high ...

a Phase 1 ready SIGLEC 10 antagonist for the treatment of solid tumors. OncoC4’s portfolio also includes preclinical programs targeting the CD24 cancer immune evasion pathway.