Indeed, levels of anti-HMG1 antibodies are elevated in patients ... The search terms we used were “sepsis”, “HMGB1”, “inflammation”, and “rheumatoid arthritis”.

In a rat model of anaphylactic shock, the administration of anti-HMGB1 antibody reduced hypotension. The red plot denotes the mean arterial blood pressure of rats treated with anti-HMGB1 antibody.

The release of a protein called HMGB1 from neurons can cause inflammation, according to a study published August 17 in PNAS. The researchers say this shows that neurons play an important role in ...