为解决他汀类药物治疗血脂异常存在副作用的问题，研究人员开展了利用计算方法筛选植物化学物作为 HMG-CoA 还原酶（HMGCR）抑制剂的研究。结果发现 5 种植物化学物有高结合亲和力，或可助力开发抗高血脂药物。 在人体中，胆固醇是细胞膜的重要组成部分 ...

3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, the rate-limiting enzyme in the cholesterol biosynthetic pathway, was an attractive target in the search for drugs to reduce plasma cholesterol ...

The statin family of drugs target HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway, and have been used successfully in the treatment of hypercholesterolemia for the past 15 years.

Redox Biology在线发表了中国科学院上海营养与健康研究所尹慧勇课题组题为Acetaldehyde Dehydrogenase 2 Regulates HMG-CoA Reductase Stability and Cholesterol Synthesis in the ...

本研究揭示了缺氧条件下转录因子Srebf和Runx3通过调控HMG-CoA还原酶（Hmgcr）表达影响胆固醇代谢的新机制。通过自发高血压大鼠（SHR）模型和体外实验，发现缺氧诱导的Hif-1α通过差异调控Srebf（抑制）和Runx3（激活）结合Hmgcr启动子区域，为心血管疾病（CVDs ...

NEW YORK, August 15 (Praxis Press). Animal studies and some cohort studies in humans have raised concerns about the carcinogenicity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase ...

Purpose: Clinical trials evaluating the effectiveness of therapy with hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors for reducing elevated C-reactive protein (CRP) levels and ...

18 Anti–HMG-CoA reductase autoantibodies may also be present in patients with autoimmune myopathy who have never been prescribed statin therapy. 8,10,17,23 Such patients, who made up one third ...

Please provide your email address to receive an email when new articles are posted on . Genetic inhibition of HMG-CoA reductase, a state that mimics long-term statin use, was associated with ...