HIV-1 entry into cells is an attractive target ... it is intriguing that X4 tropism itself does not uniformly portend rapid clinical disease progression. Furthermore, the frequency with which ...

Determinants of HIV cell tropism & chemokine receptor usage The V3 loop of HIV-1 gp120 is a primary determinant of cell tropism and chemokine receptor usage, whereas the V1/V2 region is involved ...

CCR5 antagonists only work against CCR5-tropic HIV. The British HIV Association recommends that tropism testing should take place before switching to maraviroc, using a genotypic test. Maraviroc is ...