Early steps of infection by HIV ... cell DNA with the Alu-PCR primers yielded a signal derived from the heterogeneous population of proviruses. The number of proviruses per cellular genome was ...

Traditional measures of genetic diversity (summary statistics and coalescent estimators) have helped to understand HIV diversity and distribution. Next-generation sequencing is providing a new ...

To test this idea, Lai and his colleagues treated HIV infected cells with CRISPR and used a technique to specifically amplify circular viral DNA. This enabled them to detect tiny plasmids carrying ...

The authors explain that the CRISPR-Cas genome editing tool provides a new means to target HIV DNA, which may be more ...

"Recently, the nearly complete human genome has been sequenced, but many of its functional regions remain unknown. Our findings link DNA sequence information with its functional roles. We hope ...

HIV-1 strains in humans arose from three independent ape-to-human transmissions in the early 20th century, but the viral adaptation in humans remained unknown until now. Paul Sharp and colleagues from ...