Here we identify a regulated interaction between the serine/threonine kinase HIPK2 and the ubiquitin E3 ligase Siah2 as a mechanism controlling the hypoxic response. Under normoxic conditions ...

Researchers led by Eric Huang at the University of California, San Francisco, reported that the kinase HIPK2 triggers a death cascade in response to endoplasmic reticulum stress, which is set off by ...

Oncotarget published "A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells" which reported that In this study, the authors show ...

HIPK2 upregulation is associated with increased renal cell apoptosis, proteinuria, and fibrosis. Studies in mouse models of kidney disease have identified homeo-domain interacting protein kinase 2 ...

The signaling kinase is HIPK2. While several hundred protein kinases have been identified in heart muscle cells of failing human hearts, study has so far neglected the majority of highly expressed ...

An unexplored kinase in heart muscle cells may be a good target to treat heart failure, a disease that is only incrementally delayed by existing therapies.

RLA-23174 is a first-in-class small molecule allosteric inhibitor of HIPK2 which inhibits TGF-β signaling to address FSGS and other fibrotic diseases. The phase 1 placebo-controlled study for RLA ...

After identifying HIPK2 as the target for study, Lal’s team set up several tests. First, they deleted the HIPK2 protein from heart muscle cells to see if this caused heart muscle deterioration.

RLA-23174 is a new small molecule allosteric inhibitor of HIPK2 and a potential first-in-class treatment for pan-organ fibrosis. RLA-23174 inhibits the TGF-β/Smad3 signaling pathway by affecting ...