此前有研究表明，多柔比星会影响肿瘤细胞中缺氧诱导因子 - 1α（Hypoxia-inducible Factor-1α，HIF-1α）的表达，而 HIF-1α 在肿瘤血管生成、细胞存活和代谢中发挥着重要作用。不过，化疗药物在常氧癌细胞中对 HIF-1α 水平的影响，以及相关的作用机制还不明确。

使用单细胞RNA测序（scRNA-seq）证明，在未受损伤的心脏中，特异性剔除心脏成纤维细胞中的Hif-1a导致HIF-1靶基因表达减少和间质祖细胞增加，在假 ...

线粒体靶向抗氧化剂MitoTEMPO挽救了Hif-1a突变体表型。因此，心脏成纤维细胞中的HIF-1α通过对线粒体活性氧的调节，对缺血后心脏成纤维细胞的过度激活和增殖提供了一个关键的制动机制。心脏成纤维细胞是心血管疾病中定制抗氧化疗法的潜在细胞靶标。

Hypoxia-inducible factor ... HIF-1α interacts with several protein factors including PHD, pVHL, ARD-1, and p300 ... the blocking of HIF-1a itself or HIF-1α interacting proteins inhibit tumor ...

Enarodustat是一种口服活性低氧诱导因子脯氨酰羟化酶（HIF-PHD）抑制剂，已开发的适应证为肾性贫血。 该药物于日本已完成III期临床试验，于2019年11月 ...

Hypoxia-inducible factor (HIF) prolyl hydroxylases (PHDs) are α-ketoglutarate (αKG)-dependent dioxygenases that function as cellular oxygen sensors. However, PHD activity also depends on factors ...

The proteins HIF-1a and CD24 have both been implicated in the aggressive characteristics of hypoxic cancers. A new study shows that HIF-1a drives CD24 overexpression, ... MD, PhD, director of the ...

"We discovered that the HIF-1a pathway--an oxygen regulatory pathway predominantly used early in evolution but still used during embryonic development--can act to trigger healthy regrowth of lost ...

Methods: We evaluated TUBB3 and HIF-1a expression under normoxic and hypoxic condition in human gastric cancer cell lines. The role of TUBB3 to antitumor effect of paclitaxel was checked through ...

WYNNEWOOD, PA--June 3, 2015--a study led by Ellen Heber-Katz, PhD, of the Lankenau Institute for Medical Research (LIMR), part of Main Line Health (MLH), shows that a primordial form of energy ...