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PHD-2/HIF-1α 轴介导多柔比星诱导的神经母细胞瘤血管生成:开启肿瘤 ...
PHD-2/HIF-1α 轴在多柔比星介导的血管生成中的作用:通过分子对接、分子动力学模拟和结合自由能计算,发现多柔比星能与 PHD-2 结合,抑制其活性,从而稳定 HIF-1α。实验证实,多柔比星处理的 SH-SY5Y 细胞中 HIF-1α 的基因表达和蛋白表达均上调,且细胞的糖酵解 ...
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