The following is a summary of "Impact of HBsAg reduction via siRNA treatment on natural and vaccine (BRII-179)-induced ...

Assays for hepatitis B surface antigen (HBsAg) are the most frequently used tests to detect HBV infection. Vaccination for HBV can produce transiently detectable levels of HBsAg in patients.

with the goal to maximize cumulative viral editing to achieve undetectable levels of HBsAg. With a well-tolerated safety profile and early antiviral activity established at pre-specified ...

Furthermore, the reduced levels persisted below 100 IU/mL for up to one year, with four subjects experiencing complete HBsAg loss within 21 days post-infusion. SCG101’s safety profile was ...

Two of three participants showed a substantial reduction in HBsAg after the first dose ... With a well-tolerated safety profile and early antiviral activity established at pre-specified time ...