Three of these six pathogens are antibiotic-resistant Gram-negative bacteria. Recently, antibacterial drugs against ESBL-producing Gram-negative bacteria accounted for ∼15% (2 out of 13 ...

This translational process can be excellently supported by mechanism-based modeling ... against these pathogens. Most resistant to carbapenems Gram-negative bacteria isolates are only susceptible ...

Notably, no resistance determinants ... mechanism of action could pave the way for developing next-generation antibiotics ...

In a new study, researchers at Umeå University, Sweden, show that the emergence of resistance can be understood in the mechanism of how bacteria build up defenses against being infected by viruses.

Most resistant to carbapenems Gram-negative bacteria isolates are only susceptible to polymyxins, which are commonly the main antibiotic class used against these isolates. Some shortcomings of ...