The designation is based on results from a phase 2 trial that evaluated the efficacy ... an investigational glycine transporter-1 (GlyT1) inhibitor, for the treatment of cognitive impairment ...

Furthermore, forebrain synaptic glycine and D-serine levels are regulated by the glycine transporter-1 (GlyT1 ... cis-N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl ...

Please provide your email address to receive an email when new articles are posted on . A novel glycine transporter inhibitor improved cognition after 12 weeks among individuals with schizophrenia ...

Unraveling the three-dimensional structure of the glycine transporter, researchers have now come a big step closer to understanding the regulation of glycine in the brain. These results open up ...

Unraveling the three-dimensional structure of the glycine transporter, researchers have now come a big step closer to understanding the regulation of glycine in the brain. These results ...

Here, the analysis of genetically modified mice revealed two novel disease genes associated with malfunctioning of inhibitory synapses, the collybistin and the glycine transporter 2 genes. Genetic ...

The treatment, BI 425809, inhibits a protein called glycine transporter type 1 ... The patients received daily doses of 2 mg to 25 mg of the drug on top of antipsychotics over 12 weeks.

Glycine transporter 1 (GlyT1), a glycine transporter protein, is highly co-localized with the NMDA receptor. Inhibition of GlyT1 can increase the concentration of glycine in the synaptic cleft ...

Unraveling the three-dimensional structure of the glycine transporter, researchers have now come a big step closer to understanding the regulation of glycine in the brain. These results ...