We propose to develop a novel neural stem cell (NSC)-based treatment method that will selectively target glioma cells with a potent chemotherapy agent, locally activated by the NSCs at tumor sites to ...

characterized by a high ratio of pro-tumor to anti-tumor immune cell infiltrates, acts as a seemingly insurmountable barrier to immunotherapy. Glioma stem cells (GSCs) within these tumors are key ...

Here, we propose that the asymmetrical mitosis potential of stem cells is associated with the generation of migrating tumour progenitors. Application of this speculative model to glioma proposes that ...

glioma invasion was modelled by fusing patient-derived glioma stem cells (GSCs) to Hi-Q brain organoids and used for a medium-throughput drug screening of a library of 180 compounds. Applying ...

Brain tumor stem cells are a rare population of stem-like cells in gliomas that may be responsible for tumor growth, recurrence and resistance, implying that targeting these cells may improve ...

among which SOX10 was identified as an excellent immune regulator of macrophage in gliomas. The high expression of SOX10 is related to a shorter OS in LGG, HGG, and pan-cancer groups but benefited ...

1Division of Neuro-Oncology, Brain Tumor Center, Keck School of Medicine of University of Southern California, Los Angeles, California.

Cancer Stem-like Cells,Cell Adhesion,Cell Differentiation,Cell Subsets,Cellular Differentiation,Cellular Supernatants,Customer Service,Derivatization Reaction,Dopamine,Electrode ...

A tumor that develops in any area of the brain stem is called a brain stem glioma. Types of brain stem gliomas include pontine glioma, midbrain tumor, and tumor of the medulla. In a pontine glioma (a ...

Clinical features include ataxia, cranial neuropathies, nausea, hemiparesis, and quadriparesis. Primary brain stem neoplasms are more frequent in children. Gliomas are benign and malignant central ...

Progenitor GD2-CART cells will recognize DIPG/DMG cancer cells expressing GD2, become activated, divide, and kill the cancer cells. DIPG, the leading cause of childhood brain tumor death, is uniformly ...