AGONIZING DIFFERENCES:© 2004 Macmillan Magazines Ltd.(A) GPCR agonists increase the proportion of active receptor states; inverse agonists decrease the proportion of active receptor states; and ...

GPCRs serve as a model system due to their complex interaction networks involving ligands, ions, and hydration, which facilitate structural and functional transitions. Understanding and ...

Learn how Free Energy Perturbation was used to accurately predict binding affinities for 30 ligands that bind to the lipid and GPCR interface in P2Y1.

The study specifically examines two types of GPCRs expressed on astrocytes: dopamine D1 receptors (D1R) and metabotropic glutamate receptor 5 (mGLUR5). These receptors respond to various ligands, ...

We also vigorously performed the “deorphanization” of orphan GPCRs during the project, and identified novel ligands for GPR103 and GPR7/8. We showed that the ligand of GPR103 has an essential function ...