which bind these phosphorylated GPCRs and target them for clathrin-mediated endocytosis. Clearly, the conformational state of a receptor that optimally recognizes a heterotrimeric G protein is not ...

Another significant finding was the ability to design active-state GPCR structures with unprecedented stability and reduced conformational shifts, offering new opportunities for drug design and ...

As a distinct subgroup of the GPCR superfamily ... and non-dissociation activation, where conformational shifts trigger downstream effects. This distinction underscores the versatility of aGPCRs ...