Figure 1: SNO–GAPDH interacts with SIRT1 near its nitrosylated Cys 150 residue. Mutational analysis identified Cys 387 and Cys 390, residues that are critical to SIRT1 function 14, as the sites ...

Stroke accounts for nearly 12% of all deaths worldwide, making it the second leading cause of death. In acute ischemic stroke, the ischemia and subsequent return of blood flow create oxidative and ...