Nature1 年
Trick or trap: cancer’s demise via one-carbon targeting
One-carbon Therapeutics showed that simultaneous inhibition of MTHFD2 and its isoenzyme, MTHFD1, drives the accumulation of 10-formyl-tetrahydrofolate and induces DNA damage 2. This folate ...
University of Manchester6 个月
Birth brain defect could be treated with vitamin supplement
Dr Miyan explained: “A combination of tetrahydrofolate and folinic acid – both naturally occurring substances – stimulated brain cell growth and had a significant positive effect on brain development ...