【导读】S-棕榈酰化是一种可逆的、广泛存在的翻译后修饰，但人们对其在调控铁变态反应中的作用却知之甚少。在这项研究中，团队阐明了铁变态反应的重要调节因子GPX4在半胱氨酸66上可逆地发生棕榈酰化。2025年1月20日， 深圳湾实验室尹成骞教授团队在期刊 ...

This study presents a useful finding that targeting amino acid metabolism can overcome Trastuzumab resistance in HER2+ breast cancer. The evidence supporting the claims of the authors is solid and the ...

The discovery of ferroptosis—a regulated form of cell death characterized by glutathione depletion, inactivation of glutathione peroxidase 4 (GPx4), and iron-dependent propagation of LPO—has ...

Various molecular pathways, such as glutathione peroxidase 4 (GPX4) inhibition, iron metabolism deregulation, and polyunsaturated fatty acid metabolism, converge to regulate ferroptosis.

Lipid peroxidation adversely impacts the cellular repair system, particularly the ferroptosis suppressor protein 1 (FSP1), glutathione peroxidase 4 (GPX4) pathway, and GTP cyclohydrolase 1 (GCH1 ...