铁死亡作为程序性细胞死亡的一种，自2012年被Dixon等人提出以来[1]，相关研究呈指数级增长。最近，一项发表在《Nature》杂志上的文章再次吸引了大家的目光，它揭示了溶酶体铁在铁死亡中的关键作用，并成功开发出一种名为Fento-1的小分子化合物 ...

研究发现，sorcin 在胰腺癌组织中高表达，且与患者的生存情况和肿瘤分期密切相关。进一步研究揭示，sorcin 通过非钙结合功能抑制铁死亡（ferroptosis），具体机制为：sorcin 与 PAX5 在细胞质中相互作用，抑制 PAX5 的核转位，进而降低 FBXL12 蛋白表达，减少 ALDH1A1 的 ...

Limited penetration depth into tumor tissues continues to hinder the development of nanotherapeutics for cancer treatment. A ...

A novel self-propelled ferroptosis nanoinducer developed by Southern Medical University was able to achieve deeper ...

Ferroptosis is a type of iron-dependent programmed cell death implicated in cancer, and targeting the ferroptosis pathway could be a therapeutic strategy to improve clinical outcomes.

French researchers have developed phospholipid degraders that trigger iron-catalyzed cell death in aggressive cancers like ...

In a recent review article in Life Sciences, researchers from India, the UK, and the USA highlight advancements in using nanomaterials to induce ferroptosis in cancer cells, focusing on molecular ...

From the research, it was found that ferroptosis may be a key mechanism to reverse treatment tolerance. ‘Nearly half of all cancers worldwide are digestive tract tumors. #cancer # ...