A recent study has uncovered the molecular mechanisms behind osteocyte death in melanoma bone metastasis, revealing that ferroptosis—an iron-dependent form of cell death—plays a central role in the ...

高度近视在全球的患病率呈上升趋势，已成为严峻的健康挑战。高度近视性白内障作为高度近视最常见的并发症，发病年龄比年龄相关性白内障更早，严重影响患者工作期间的生活质量。由于晶状体核通常较硬，HMC 的手术干预难度较大，因此深入了解其发病机制对开发潜在治疗方法至关重要。

This study presents a useful finding that targeting amino acid metabolism can overcome Trastuzumab resistance in HER2+ breast cancer. The evidence supporting the claims of the authors is solid and the ...

Using an intracardiac melanoma metastasis mouse model and RNA sequencing, the team identified significant alterations in gene ...

This view radically changed with the discovery of apoptosis and its specific signaling pathways in the 1990s ... and other liver diseases as ferroptosis. DILI is broadly categorized into intrinsic ...

Efficacy of plogosertib (CYC149462), a novel orally bioavailable PLK1 inhibitor, on patient-derived models of colorectal cancer. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal ...

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain. Bone metastasis is associated ...

Glaucoma is a complex and multifactorial neurodegenerative disorder primarily characterized by the progressive loss of retinal ganglion cells (RGCs) and their axons, leading to irreversible visual ...

scavenging pathways such as macropinocytosis, and mechanisms of cell death. We investigate cell death mechanisms that have unique effects on cell populations, including entosis that supports the ...

Sensitizing K-Ras G12D mutant colorectal patient-derived organoids via ferroptosis pathway. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal Cancers Symposium. This abstract does ...