Mechanistically, ferric ammonium citrate (FAC) activates lipid peroxidation in primary lung epithelial cells, which was suppressed by ferroptosis inhibitors, ferrostatin-1 and liproxstatin-1.

The application of ferroptosis inhibitors can alleviate the development of AD in both cellular and animal models. Herein, a series of dual-functional hydroxylated chalcone derivatives by ...

A key discovery was the activation of the HIF1α-HMOX1 axis, which drives excessive autophagy and ferritin degradation, leading to intracellular iron overload and lipid peroxidation, hallmarks of ...

Triple-negative breast cancer (TNBC) is one of the most aggressive and difficult-to-treat forms of breast cancer, lacking targeted therapies due to its molecular characteristics. Tumor-associated ...

Efficacy of plogosertib (CYC149462), a novel orally bioavailable PLK1 inhibitor, on patient-derived models of colorectal cancer. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal ...