An allosteric inhibitor of acetyl-CoA carboxylase reveals a metabolic liability of non-small-cell lung cancer and slows tumor growth alone and in combination with chemotherapy in mouse models.

The initial step for such fatty acid synthesis is acetyl-CoA carboxylation to malonyl-CoA with the help of the enzyme acetyl-CoA carboxylase, which is mostly taking place in liver cells, but also ...

Fatty acids are converted into fatty acyl-CoA by ACSL and transported via CPT-1 before being oxidized to acetyl-CoA. Fatty acid β-oxidation is promoted by PPARα.

Odd-chain fatty acids are oxidized identically to even-chain fatty acids, except that in the final round of β-oxidation, 1 molecule of each of acetyl-CoA and anaplerotic propionyl-Co are produced ...

Organisms across all kingdoms of life crucially rely on a molecule called acetyl-CoA that fuels essential biochemical processes in cells, such as the production of fatty acids and cholesterol ...

Researchers have identified a mutation in a common oncogene that may play an important role in colon cancer. Their findings ...

Scientists at Fox Chase Cancer Center have identified a mutation in a common oncogene—a gene that can cause cancer—that may ...

The researchers also observed that 6-PPDQ exposure decreased acetyl CoA and pyruvate contents, which are important for the control of citric acid cycle. Acetyl CoA generated from pyruvate is a key ...

Now, researchers at the Salk Institute, along with academic and industry collaborators, have described a method (“Inhibition of Acetyl-CoA Carboxylase Suppresses Fatty Acid Synthesis and Tumor ...

Overview. Name: Acetyl-l-carnitine HCI Synonyms: ALCAR Therapy Type: Supplement, Dietary Target Type: Other Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Discontinued) ...