衰老过程伴随着基因突变和表观遗传变化的累积，这些变化逐渐破坏分子和细胞水平的功能稳态，导致蛋白质稳态丧失和线粒体功能异常。在神经退行性疾病背景下，蛋白质稳态的丧失极大地促成了包括 β-淀粉样蛋白（Aβ）、过度磷酸化的 tau ...

为解决 FTLD 中自噬 / 线粒体自噬作用不明的问题，捷克研究人员开展 FTLD 患者生物流体中线粒体自噬生物标志物研究。结果发现 FTLD 与 AD 的生物标志物存在差异。这为了解疾病机制、开发针对性疗法提供依据，推荐科研读者阅读。 在神经科学的神秘世界里 ...

为探究 mtDNA 突变在 ALS - FTLD 发病机制中的作用，研究人员用 hiPSCs - 衍生脑类器官研究，发现 C9ORF72 突变星形胶质细胞 mtSNV 负担高，或助力靶向治疗。

FTLD patients with professions ranked highly for verbal skills, such as chief executive, showed atrophy in right temporal lobe. In those with professions ranked lower for verbal skills ...

Neumann et al. have identified the ubiquitinated protein that forms inclusion bodies in neurons of both individuals with frontotemporal lobar degeneration (FTLD) and those with amyotrophic lateral ...

On the surface, the movement disorder amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the cognitive disorder frontotemporal lobar degeneration (FTLD), which underlies ...

FTLD is a major cause of dementia, with a prevalence second only to that of Alzheimer's disease and Lewy body dementia. Mutations in the VCP gene are known to cause hereditary FTLD.

RBI's effort is not the first to try to undercut fraudsters and phishers by using domain names. fTLD Registry Services governs the top-level domain .bank. It reserves the domain for retail banks, ...

The blood-based biomarker performed slightly better in Alzheimer's-related syndromes (AUC 0.98, 95% CI 0.95-1.00) than in frontotemporal lobar degeneration (FTLD)-related syndromes (AUC 0.89 ...