Over a decade ago, a group from the Section of Dialysis and Extracorporeal Therapy at The Cleveland Clinic, OH, developed a bicarbonate-based dialysate for use during continuous renal replacement.

In final bicarbonate dialysis the initial volume and the physiologic pH value of the processed plasma is reconstituted. The H.E.L.P. apheresis (heparin-induced extracorporeal LDL precipitation ...