Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and ...

Extrachromosomal DNAs (ecDNAs) are circular DNA structures located in the nuclei of cells outside chromosomes. They were originally discovered in chromosome spreads of cells obtained from ...

A type of circular DNA not found on chromosomes, termed extrachromosomal DNA, can aid cancer growth by harbouring cancer-promoting genes (oncogenes) 1.The unique structure of extrachromosomal DNA ...

City of Hope co-led the first study to demonstrate that characterizing genetic material near chromosomes forecasts how mutated, cancer-causing genes reengineer DNA and alter the tumor microenvironment ...

Research published in Nature Genetics on Oct.14, by Yale Cancer Center researchers at Yale School of Medicine, found a higher concentration of a specific kind of DNA—extrachromosomal or ecDNA ...

In the Cambridge samples, extrachromosomal DNA was not detected in non-dysplastic or low-grade Barrett’s esophagus samples, but was found in 25% of patients with early-stage esophageal adenocarcinoma ...

Boundless Bio is testing a small-molecule drug against what scientists call extrachromosomal DNA, in an initial clinical trial of patients with solid tumors. The company, ...

I n contrast to chromosomal DNA, which is replicated and divvied up equally among daughter cells during cell division, the extrachromosomal DNA (ecDNA) found in some cancer cells is not always split ...

Massive extrachromosomal elements named after the hive-minded cyborg villains in Star Trek may be the first of their kind. Small circles of extrachromosomal DNA appear to be widespread in mammals, and ...

Although extrachromosomal DNA only appears in about 15% of patient samples in the reported study, that subset might be particularly aggressive or prone to therapy resistance.

Research published in Nature Genetics on October 14, by Yale Cancer Center researchers at Yale School of Medicine, found a higher concentration of a specific kind of DNA — extrachromosomal or ecDNA — ...