染色体外环状 DNA（extrachromosomal circular DNA，eccDNA）是一种存在于真核细胞（包括人类细胞）常规染色体 DNA 之外的迷人遗传物质形式。自 20 世纪 60 年代被发现以来，eccDNA 就与癌症进展以及年龄相关疾病有着紧密联系。

在人体的正常细胞中，绝大多数DNA分子紧密缠绕并压缩在染色体中。然而在很多癌细胞中，还有一种被称为“染色体外DNA”（extrachromosomal DNA，简称 ...

引言在癌症治疗领域中，研究人员不断揭示新的机制，以便更好地理解肿瘤如何规避治疗并迅速进化。近年来，染色体外DNA（extrachromosomal DNA, ecDNA ...

A type of circular DNA not found on chromosomes, termed extrachromosomal DNA, can aid cancer growth by harbouring cancer-promoting genes (oncogenes) 1.The unique structure of extrachromosomal DNA ...

Extrachromosomal DNAs (ecDNAs) are circular DNA structures located in the nuclei of cells outside chromosomes. They were originally discovered in chromosome spreads of cells obtained from ...

Although extrachromosomal DNA only appears in about 15% of patient samples in the reported study, that subset might be particularly aggressive or prone to therapy resistance.

Although extrachromosomal DNA only appears in about 15% of patient samples in this study, that subset might be particularly aggressive or prone to therapy resistance.

City of Hope co-led the first study to demonstrate that characterizing genetic material near chromosomes forecasts how mutated, cancer-causing genes reengineer DNA and alter the tumor microenvironment ...

In the Cambridge samples, extrachromosomal DNA was not detected in non-dysplastic or low-grade Barrett’s esophagus samples, but was found in 25% of patients with early-stage esophageal adenocarcinoma ...

I n contrast to chromosomal DNA, which is replicated and divvied up equally among daughter cells during cell division, the extrachromosomal DNA (ecDNA) found in some cancer cells is not always split ...