Hydrolysis occurs mostly in the liver and is one type of Phase I metabolism, which is mostly triggered by esterase and amidase. Esterase splits esters into an acid and an alcohol in a chemical ...

2a). Figure 2: Mutations in the esterase PfPARE are responsible for resistance to pepstatin esters. We performed in-cell metabolism experiments to determine the fate of pepstatin and its ester ...

The gastrointestinal wall is a significant site of first-pass metabolism for oral drugs, which is commonly associated with CYP450 and UGT enzymes. However, contributions of esterase activities in the ...

Esterase metabolism and biotransformation to an inactive metabolite provide unique pharmacokinetic differences compared with other benzodiazepines. In May, the Centers for Medicare & Medicaid ...

The FDA approved CSL Behring’s subcutaneously administered C1 esterase inhibitor (human), Haegarda, for routine use in preventing hereditary angioedema (HAE) attacks in adolescent and adult ...