Despite major interest in this pathway for cancer drug discovery, no drugs have yet been approved that act specifically against PI3K or its downstream regulator, AKT. However, several drugs that ...

为了弄清楚这些问题，湖北医药学院的研究人员在《Scientific Reports》期刊上发表了题为 “Metformin inhibits the growth of small cell lung cancer cells via suppression of the EGFR/AKT/AMPK/mTOR pathway” 的论文。研究发现，二甲双胍能够通过抑制 ...

The study delves into the well-established role of EGFR-mediated signaling in CRC ... downstream molecules within the RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. Furthermore, the study explores ...

This figure illustrates the major signaling pathways and their intricate crosstalk in BC, focusing on the GPCR, RTKs, RAS/RAF/MEK1/2/ERK1/2, MAPK, HER2, PI3K/Akt/mTOR, Wnt/β-catenin, NF-κB ...