The elaboration of an efficient immune response against pathogens involves complex intracellular antigen-processing events. Endogenous antigens such as viral proteins synthesized by infected host ...

Here we demonstrate that cross-presentation of soluble antigen occurred in an early endosomal compartment distinct from the endoplasmic reticulum where endogenous antigen is loaded onto MHC class I.

In the endogenous pathway, MHC class I molecules present endogenous antigens derived from pathogen-specific proteins produced within infected cells. However, in the exogenous pathway, MHC class II ...

Examples include bacteria, viruses, fungi, and other pathogens. These antigens are typically recognized by the immune system as non-self and trigger an immune response to eliminate the invading ...

Certain peptides are preferentially loaded onto MHC I, further processed for immune surveillance (antigen processing) and presented on the cell surface. Peptides that come from normal endogenous ...

Certain peptides are preferentially loaded onto MHC I, further processed for immune surveillance (antigen processing) and presented on the cell surface. Peptides that come from normal endogenous ...

SQZ AACs are a novel cellular immunotherapy candidate designed to transport tumor-specific antigen and TLR agonists to the patient’s endogenous, professional, antigen presenting cells in vivo.

Antigen escape is an even more significant ... bystander immunity in the form of epitope spread with activation of endogenous T cells directed against whatever neoepitopes exist in an individual ...

“We reasoned that augmenting the expression and thus the presentation of endogenous antigens in tumors could amplify the ‘nonself’ identity of cancer cells, thereby flagging them for immune ...