In 1975, Barbara Pearse identified the protein that coated the endocytic vesicles. She named the protein clathrin for its ability to form lattice-like structures (Pearse 1976). By sequencing ...

In this case, it should be vesicle formation that is rate limiting. Rab5 catalyses both homotypic endosome fusion and the fusion of newly formed, clathrin-coated endocytic vesicles with early ...

Homotypic fusion between late endosomes. (A) Time-lapse imaging of endocytic vesicles in VE cells. (B) By labeling of VE ...

1. Chaperone-assisted Adaptor Protein Assembly (CAPA). Our group discovered the CAPA pathway while identifying endocytic regulators. Adaptor proteins (APs) are heterotetrameric complexes that function ...

The maintenance of synaptic transmission requires that these vesicles be retrieved by a reverse process, i.e. endocytosis. How is this endocytic activity and subsequent formation of fusion-competent ...

Our lab is interested in the molecular mechanisms of cargo sorting along the endocytic pathway with particular emphasis on the regulation of the clathrin coated vesicle cycle by rab5 and reversible ...