Synthetic chemicals and plastics are useful and indispensable in our lives. On the other hand, the world is grappling with ...

Many of these mutations affect genes that are involved in endocrine signalling pathways. Attenuation of signalling through the insulin/insulin-like growth factor-1 (IGF1) pathways prolongs the ...

Parabens, widely used preservatives in cosmetics, pharmaceuticals, and food products, have raised significant health concerns ...

Approximately 75% of all breast cancers are ER-positive, and so targeting ER signaling with endocrine therapy has been and continues to be the backbone for the treatment of ER+ breast cancer.

1 Endocrine organs produce various hormones ... 11 The interaction between these hormones and their cell surface receptors may directly activate intracellular signaling pathways, influencing functions ...

As hormonally-responsive tissues, the breast and thyroid share endocrine signaling. Breast cells are responsive to thyroid hormone signaling and are affected by altered thyroid hormone levels.

have made groundbreaking discoveries in endocrine signaling through nuclear receptor research. Their discoveries include the elucidation of the key signaling pathways governing cholesterol ...

Usually the body’s endocrine system works like a well-oiled ... it can activate a receptor that can lead to a cascade of signaling that is not supposed to happen in that moment,” says Marina ...

For example combining PR targeted therapy with endocrine therapy or using selective modulator of PR signaling may further improve the outcome. Overcoming Resistance: While ER+/PR+ tumor generally ...

As recommendations suggest extending hormone-based breast cancer treatment to 10 years for some patients, a new study sheds light on whether patients are opting for it.