Interleukin-6 (IL-6) is a central mediator of the sepsis ... IL-6 levels were significantly (p < 0.001) elevated in both blood culture positive and culture negative sepsis. For sepsis, plasma ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...