Such rearrangements may be called ‘electrophilic rearrangements’. Nature - A New View of the Arylhydroxylamine Rearrangement. Skip to main content. Thank you for visiting nature.com.

Electrophilic rearrangements are chemical reactions in which atoms in the same molecule are rearranged. This ultimately creates a new chemical compound.

The problem, however, is that we don't know exactly how most reactive electrophilic drugs work, which makes it difficult to predict their effects and outcomes, and efficiently design new ones.