The maturation of early endosomes into lysosomes is marked by a progressive decrease in interior (luminal) pH, which is crucial for the activation of resident enzymes that degrade exogenous ...

The ER, Golgi apparatus, and lysosomes are all members of a network of membranes, but they are not continuous with one another. Therefore, the membrane lipids and proteins that are synthesized in ...

However, early intervention is likely the key to stopping ... dysfunction through the dysregulation of late endosome to lysosome-ER contact sites, Developmental Cell (2024). DOI: 10.1016/j.devcel.

Fats and other cellular materials reach the lysosome through three main pathways: endocytosis, phagocytosis, and autophagy. In endocytosis, the cell takes in materials from outside by wrapping ...