E-selectin expression is induced by a pro-inflammatory milieu caused by the primary tumor, which might depend on disinhibition of NF-kB in the proteasome. Methods: in vivo, ex vivo and in vitro ...

The serum or plasma concentrations of soluble ICAM, VCAM, and E-selectin in patients with a variety of malignancies are associated with disease progression or prognosis. 9–11 The primary target of ...

Previous studies have identified a CAM termed E-selectin as a promising target. Its inhibition can potentially reduce the metastatic burden in lung and colon cancers with minimal side effects.