Variations in the NAT2 gene can lead to different acetylation statuses among individuals, which can influence their susceptibility to drug-induced hepatotoxicity, particularly in the context of ...

Drug-induced hepatitis is uncommon and generally unpredictable. Hepatotoxicity may be related to the drug itself, or to chemically reactive metabolites which can bind covalently to hepatic ...

Recent draft guidance highlights the challenges that industry and regulators face to predict rare drug-induced liver injury. At the end of August 2008, the consultation period ended for comments ...

This may hint at what lies ahead as we navigate the (mostly erroneous) tendency to identify every cell death process in drug hepatotoxicity and other liver diseases as ferroptosis. DILI is broadly ...

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according to the Drug-Induced Liver Injury Network, a multicenter, observational program that collects data from U.S.

At least six hepatic health parameters ... and finalize the experiment plan Customer supplies the required amount of drug(s) Two weeks to complete cell culture The DILI test can determine the ...