Ten Drosophila genes, orthologous to candidate human AD susceptibility genes, were validated in our functional screen. For example, loss-of-function in cindr, the fly ortholog of human CD2AP, enhances ...

Current Drosophila transgenic RNAi resources use long hairpins as silencing triggers 1.However, for reasons unknown, long hairpins are ineffective for gene silencing in the female germline, a ...

A wide variety of animals have been previously used in animal testing, including mice, flies, and monkeys. A particularly useful model organism is Drosophila melanogaster, commonly known as the ...