Nephronophthisis (NPH) is a recessive cystic kidney disease responsible for 10% to 20% of pediatric end-stage renal disease cases. NPHP1 (nephrocystin 1) is the most frequently implicated among over ...

Disruptions in the regulation of TGF-β and HIPPO pathways contribute to liver diseases. In fibrosis, the TGF-β pathway promotes the activation of hepatic stellate cells, leading to extracellular ...

Hippo signalling is a cell signalling pathway that controls organ size. Activation of Hippo results in a series of phosphorylation events that culminate in the phosphorylation and cytoplasmic ...