In traditional directed evolution approaches ... or when more than one property is being selected for. “We need the enzyme to be highly active, stable in the process, and tolerant of high ...

Scientists have long struggled to target proteins that lack defined structure and are involved in cancer, neurodegenerative ...

In view of the recent emergence of directed evolution and a host of other tools for biocatalyst discovery, it came as no surprise that development of enzymes with remarkable physical and catalytic ...

Life has evolved over billions of years, adapting to the changing environment. Similarly, enzymes—proteins that speed up ...

Enzymes originally evolved in high-temperature environments and later adapted to lower temperatures as Earth cooled. Scientists discovered that a key shift in enzyme function occurred over ...

Researchers found that using a process called directed evolution, in which the amino acid sequence of an enzyme is randomly changed until it can perform a desired function, proved much more fruitful.

Using techniques like directed evolution, we can engineer enzymes to optimize them towards our desired activities by mimicking the natural selection process in the laboratory. To this end we are ...

Researchers found that using a process called directed evolution, in which the amino acid sequence of an enzyme is randomly ...

In comparison to other methods such as directed evolution, rational design is less time consuming as it does not require large library screening. Scientists use this strategy to engineer protein-based ...

Arnold pioneered directed enzyme evolution and has used directed evolution to optimize biocatalysts for applications in alternative energy, chemicals, and medicine. Her methods are used throughout the ...

Arnold pioneered directed enzyme evolution and has used directed evolution to optimize biocatalysts for applications in alternative energy, chemicals, and medicine. Her methods are used throughout the ...