Figure 1: Systemic increase in Flt3l amounts, Flt3-dependent bone marrow activation and dendritic cell expansion during P. chabaudi infection. Figure 2: Role of Flt3l-responsive CD8-α + langerin ...

Overall, patients receiving Flt3L pre-treatment saw much more robust transcriptional ... Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell ...

In non-lymphoid tissues, DCs employ scavenger receptors like Dendritic and Epithelial ... Tyrosine Kinase 3 Ligand (Flt3L) and CD40 agonism, and insights from single-cell ribonucleic acid (RNA ...

Oncolytic viruses trigger immunogenic cell death in tumors, releasing signals that activate innate immune cells and promote tumor-specific T-cell responses. While some oncolytic viruses, including FDA ...

for example against pathogens or cancer cells. The special thing about dendritic cells: They only live for about a week and during this time they continuously migrate through the body's tissues.

Their job: alert the immune system to toxic invaders so it can mount an attack. But these sentries – known as dendritic cells – often fail to warn of cancer’s arrival. Why? Scientists surmise that, ...

Proteogenomic analysis identified IFNγ as a driver of conventional dendritic cell type 2 maturation into migratory dendritic cells, which secreted cytokines Interleukin-12 and Interleukin-15.

Apr. 30, 2021 — Dendritic cells are divided into Type 1 (DC1) and Type 2 (DC2) dendritic cells. Each type fulfills different functions: DC1 provide an immune response to bacteria and viruses ...