Figure 1: Systemic increase in Flt3l amounts, Flt3-dependent bone marrow activation and dendritic cell expansion during P. chabaudi infection. Figure 2: Role of Flt3l-responsive CD8-α + langerin ...

Fms-like tyrosine kinase-3 ligand (Flt3L) uniquely binds the ... stem cells (HSCs), early progenitor cells, immature thymocytes and steady-state dendritic cells (DCs) and induces their ...

such as dendritic cells (DCs), are essential for effective T cell responses,” explained Dr. Fling. “Flt3 [fms-like tyrosine kinase 3] ligand, a growth factor for DCs, was discovered ~27 years ago at ...

Oncolytic viruses trigger immunogenic cell death in tumors, releasing signals that activate innate immune cells and promote tumor-specific T-cell responses. While some oncolytic viruses, including FDA ...

Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma. Clinical Cancer Research , 2023 ...

RENEW (NCT04963413) is designed to evaluate the ability to generate pp65 Lysosomal Associated Mediated Protein (LAMP) RNA-pulsed dendritic cells in patients who have completed standard external ...

Dubodencel, also known as DOC1021, is a first-in-class, double-loaded autologous dendritic cell therapy that uniquely combines tumor lysate and amplified tumor-derived mRNA. The immunotherapy is ...