Figure 3: Degranulation controls the appearance of FasL on the cell surface. Figure 4: FasL contains signals for targeting to the secretory lysosomes. Figure 5: Subcellular distribution of FasL ...

Patients with autosomal dominant vibratory urticaria have localized hives and systemic manifestations in response to dermal vibration, with coincident degranulation of mast cells and increased ...

immunoglobulin E (IgE) antibodies, which are immune system proteins mast cell degranulation, which is the release of chemicals from specialized immune cells IgE-mediated reactions occur when ...

At the ongoing AAAAI meeting in San Antonio, researchers from Escient Pharmaceuticals Inc. presented preclinical data for the Mas-related G-protein coupled receptor X2 (MRGPRX2) antagonist EP-262, ...

Mast cell degranulation produces inflammation, recruiting other immune cells such as monocytes and neutrophils, and T lymphocytes. These cells also affect the vascular tone and permeability ...

The infant had also been treated with inhibitors of mast-cell degranulation (cromolyn), of histamine H 1 and H 2 receptors (hydroxyzine and ranitidine, respectively), and of the cysteinyl ...

Studies on mastocytosis revealed a subgroup of patients presenting symptoms of increased MC degranulation, defined as mast cell activation syndrome (MCAS). This population includes patients with ...