DNA methylation and histone modification ... In the second step, a G9a-associated complex coordinates histone deacetylation followed by local methylation of H3K9, thereby generating local ...

Aging involves complex cellular and molecular changes, including epigenetic modifications like Deoxyribonucleic acid (DNA) methylation and histone marks. Age predictors, or "clocks," have been ...

The basic organizational unit of the genome is a nucleosome, which is a short segment of DNA wound around a complex of eight histone subunits. Each of these histones has a tail region which can be ...

They discovered that despite relatively weak binding by an essential protein—histone variant CENP-A/Cse4—to DNA ... These findings published in the EMBO Journal bring into focus the complex regulation ...

The review highlights the complex biology of cccDNA, which forms minichromosomes in the infected liver cell nucleus. These minichromosomes bind with histone and nonhistone proteins, becoming ...