How is all of that DNA packaged so tightly into chromosomes and squeezed into a tiny nucleus? Histones are a family of small, positively charged proteins termed H1, H2A, H2B, H3, and H4 (Van Holde ...

Loss of core histones is now observed in aged cells and may contribute to this phenomenon. Histone loss is coupled to cell division and seems to be triggered by telomeric DNA damage. Figure 2 ...

The mechanism of a peculiar type of heterochromatin, used by embryonic stem cells to silence 'parasitic' DNA-elements within the context of their highly dynamic pluripotent chromatin. Disclaimer ...

The team thought it might be a good candidate for finding histones because the bacterium changes size throughout its lifecycle and thus would need to carefully time DNA compression and unwinding. As a ...

The study shows that missegregated chromosomes do not activate the innate immune response through STING, likely due to the natural packing of the genomic DNA by histones. This is notable ...