forks converge until all intervening DNA is unwound; any remaining gaps are filled and ligated; catenanes are removed; and replication proteins are unloaded. In eukaryotes, most termination sites ...

At each cell division in humans, DNA replication starts from 50,000 DNA replication origins, which are at specific locations along the chromosomes and from which DNA synthesis proceeds ...

The enormously long genomic DNA molecules in eukaryotic organisms must be tightly folded to fit into the micrometric ...

In eukaryotes, DNA replication initiates at many replication origins that are distributed along the length of each chromosome arm. At each origin, two replication forks are established that travel in ...

Eukaryotic DNA replication occurs at many points within the chromosome, therefore replication forks meet and terminate at many points. DNA replication must be stopped or blocked for termination to ...

Our lab studies the mechanism of eukaryotic chromosome ... and faithful chromosome replication is of fundamental importance for genome maintenance during normal cell proliferation. We employ fully ...

Among them, the proliferating cell nuclear antigen (PCNA) is a key replication protein. This ring-structured molecule encircles chromosomes ... PCNA for the termination during DNA replication ...

The enormously long genomic DNA molecules in eukaryotic organisms ... as well as for DNA replication, repair, and segregation to daughter cells. Chromosomes can be considered as self-organized ...

To build you, and then keep you alive, the DNA in your cells needs to undergo replication every day to duplicate your chromosomes ... is split into three groups: eukaryotes (including us ...

DNA methylation has been shown to have an important role in several eukaryotic processes, such as embryonic development, genome imprinting, inactivation of X-chromosome, and generally preserving ...