真核生物基因组DNA高度折叠形成染色质，不仅成为遗传和表观遗传信息的载体，也在维持基因组稳定性中发挥重要作用。然而染色质结构具有双重效应：核小体作为染色质的基本单元，在保护DNA的同时，也成为DNA复制和遗传信息解读等过程中的物理障碍。以DNA复制为例，细胞通过动态调控机制克服这一障碍--复制叉前方的亲本核小体被暂时解离以确保复制机器顺利行进，而子代DNA链则在复制叉后重建核小体阵列。这一时空偶联 ...

Z-DNA has a left-handed double helix structure. It is said to be found during the start of a gene. DNA replication occurs in the S phase of the cell cycle. DNA replication is the process where ...

Revising the structure and replication of DNA? Test your knowledge of the process and need for DNA replication with this Higher Biology quiz.

Save guides, add subjects and pick up where you left off with your BBC account. The famous X-ray diffraction photograph of DNA taken by Rosalind Franklin, known as photograph 51.

We employ fully reconstituted yeast and human DNA replication systems to investigate the structure and biochemical mechanism of the eukaryotic replication machinery. A particular focus of the lab is ...

If DNA bridges persist between chromosomes during cell division, chromosomes are abnormally segregated, leading to genetic ...

"The replication process is carried out ... G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA ...

When organisms encounter problems -- what scientists call "replication stress ... bases (represented by G in the DNA code) can fold into a DNA structure called a G-quadruplex, or G4 for ...

In the double helix structure of DNA, thymine forms a base pair with adenine through two hydrogen bonds. This specific pairing is known as complementary base pairing and is essential for the stability ...

But James Watson and Francis Crick's claim was a valid one, for they had in fact discovered the structure of DNA, the chemical that encodes instructions for building and replicating almost all ...

RNA only has one strand, but like DNA, is made up of nucleotides. RNA strands are shorter than DNA strands. RNA sometimes forms a secondary double helix structure, but only intermittently. DNA is a ...