Survival is promoted through repair of these lesions by a number of DNA repair pathways. The efficacy of anticancer drugs is highly influenced by cellular DNA repair capacity. Inhibitors of DNA ...

Throughout the course of our lives, DNA can break in response to natural and environmental factors. However, our bodies have dedicated enzymes and pathways which can repair our broken DNA back ...

“DNA damage response pathways cause replication forks to slow down progression by about ten-fold. This ten-fold slowdown means that synthesis of the cell’s genome, which usually takes about 12 hours, ...

Drs Olga Brieieva and Martin Higgs discuss in vitro genomic models for predicting clinical resistance to PARP inhibitors for ...

Indels are primarily generated through the BER pathway, with 1-bp insertions ... Molecular mechanisms of DNA lesion and repair during antibody somatic hypermutation. Science China Life Sciences.

"We found that the manner in which tumor cells die after radiotherapy depends on the engagement of specific DNA repair ...

“In one particular DNA repair pathway, it takes about 30 proteins to go from finding the pothole to putting in the repair patch. While we can’t observe all of these proteins at once, we can ...

These are considered the most severe type of DNA damage, capable of causing genetic mutations or cell death. Cells maintain genome integrity by having various pathways to repair DSBs. Among the ...

Published online May 16 in the journal Cell, the report describes the molecular mechanism behind a DNA repair pathway that counters the mistaken inclusion of a certain type of molecular building ...

These are considered the most severe type of DNA damage, capable of causing genetic mutations or cell death. Cells maintain genome integrity by having various pathways to repair DSBs. Among the ...