Survival is promoted through repair of these lesions by a number of DNA repair pathways. The efficacy of anticancer drugs is highly influenced by cellular DNA repair capacity. Inhibitors of DNA ...

"We found that the manner in which tumor cells die after radiotherapy depends on the engagement of specific DNA repair ...

DNA damage response, or DDR for short, is the technical term for this. Specific signaling pathways usually initiate the immediate recognition and repair of DNA damage, thus ensuring the survival ...

The researchers were working on a DNA repair pathway, known as the Fanconi Anaemia [FA] pathway, which was identified more than twenty years ago. DNA is constantly damaged throughout our lives by ...

A study reveals significant genomic differences in metastatic prostate cancer among veterans, highlighting the need for ...

Drs Olga Brieieva and Martin Higgs discuss in vitro genomic models for predicting clinical resistance to PARP inhibitors for ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...

“These pathways are important for preventing exacerbation of DNA ... greatly increasing the time cells have to repair DNA damage.” For years, Melendy and his colleagues have been studying two types of ...

A new hereditary condition has been discovered that affects patients' ability to repair DNA—leaving them both at greater risk ...

Precision gene editing is crucial for treating genetic diseases, as it enables targeted correction of specific mutations. A ...

T cells are the immune system’s frontline fighters. When they detect danger, they rapidly multiply and transform into effector cells that destroy pathogens.