为解决寡核苷酸药物穿越血脑屏障（bbb）及快速降低毒性蛋白的挑战，研究人员开发脑穿透性 dna 纳米花结合寡核苷酸靶向蛋白降解嵌合体（oligo-protac）。以 fus 为模型，证实其通过泛素 - 蛋白酶体通路降解 fus，单次静脉注射可穿透 bbb 并持续降靶，为神经退行性疾病治疗提供新策略。

近日，北京大学化学与分子工程学院本科校友、美国威斯康星麦迪逊大学博士毕业生、目前正在斯坦福大学从事博士后研究的朱彦宇和所在团队研发出一种高时空分辨率的活细胞 DNA 成像技术 Oligo-LiveFISH。该技术基于 sgRNA ...

Getting high-quality, synthetic sequences is currently a bottleneck for RNA-based therapeutics; however, researchers are exploring the potential of enzymatic approaches for oligonucleotide synthesis ...

Today's DNA synthesis platforms are built on the same technology that was developed in the 1980s. ... developed in the 1980s, is the standard method for DNA oligo synthesis.

Therefore, chemical synthesis can only produce relatively short oligos. For gene synthesis, i.e., construction of double-stranded DNA molecules longer than a few hundred base pairs, several oligos ...

Dublin, Feb. 08, 2023 (GLOBE NEWSWIRE) -- The "Oligonucleotide Synthesis Markets - Forecasts by Oligo Length, Application, and Product - With Executive and Consultant Guides 2023 to 2027" report ...

Covina, Nov. 14, 2023 (GLOBE NEWSWIRE) -- Oligonucleotide synthesis is a process in molecular biology and biotechnology that involves the chemical synthesis of short DNA or RNA molecules, known as ...